Rheumatoid arthritis patient antibodies highly recognize IL-2 in the immune response pathway involving IRF5 and EBV antigens.

Interestingly, over 30% of our RA cohort displayed anti-IL-2/IRF5 Abs in a highly significant double positivity ( p < 0.0001) and a more frequent multiple seroreactivity was observed in RA patients compared to healthy controls (Table 1 ).

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