Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H₂O₂-Dependent Manner.

Interestingly, the treatment with GC/AscH − prior to 2 Gy IR resulted in cancer cell killing that was at least additive and significantly exceeded that seen with either agent alone in two cell lines, with a third trending toward significance ( Figure 5 ). 4.

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