borderline significanceP = 0.050
The min TDM had a 10.8% decrease at 12 months compared to baseline (borderline significance in pairwise comparisons: −33.02 (−66.08 to 0.033), P = 0.050) and the max TDM was numerically reduced at each visit (Table 4 ), but these MRI summary measures did not display a main effect of visit in this relatively small cohort.