Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly.

Nat Commun · 2018 · PMC5790807 · PMID 29382830

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highly significantno p-value reported

This represents a highly significant bias toward antagonistic risk SNPs (binomial test p -values of 7.28×10 −15 and 1.99×10 −9 , comparing the frequency of antagonistic risk SNPs for degenerative ageing diseases and cancer to non-ageing-associated traits, respectively, Supplementary Note 8 ).

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