Barely Significant
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Carotid artery wall shear stress is independently correlated with renal function in the elderly.

Oncotarget · 2018 · PMC5797047 · PMID 29435176

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an increasing trendno p-value reported
There was an increasing trend in NO, and decreasing trends in ET-1, ICAM-1, and VCAM-1 from Q1 to Q4.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.