Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers.

J Biol Chem · 2018 · PMC5798299 · PMID 29222332

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highly significantp = 0.01actually significant

Compared with SOSIP.664 and SOSIP.v5.2, a highly significant reduction in MW965.26 neutralization was seen for SOSIP.v5.2 S306L/R308L immunized rabbits of 154- and 12-fold respectively ( p = 0.01 for SOSIP.v5.2 S306L/R308L versus SOSIP.v5.2 and p = 0.001 for SOSIP.v5.2 S306L/R308L versus SOSIP.664, respectively).

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