In vitro RNA-seq-based toxicogenomics assessment shows reduced biological effect of tobacco heating products when compared to cigarette smoke.

5C ) and were confirmed in the independent qPCR repeat, whilst CYP26A1 was borderline significant when tested by qPCR (Fig. 7B ).

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“Inflammation” (pFDR = 5.23e −11 ), “response to wounding” (pFDR = 4.05e −10 ), “response to chemicals/xenobiotics” (pFDR = 1.65e −09 ), and “cell migration” (pFDR = 1.42e −09 ) were highly significant (Supplementary Table S14 ).

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