highly significantP < .0001
Protection was dose dependent, and there was a highly significant correlation between circulating in vivo HI and MN antibody titers and mice survival (nonparametric Spearman correlation r = 0.9, P < .0001) ( Hohenadl et al., 2014 ) A RCT of patients hospitalized with severe A(H1N1)pdm09 virus infection in 5 hospitals in Hong Kong compared treatment with immune IVIG prepared from plasma of persons who had recovered from the disease against treatment with normal IVIG manufactured before 2009 ( Hung et al., 2013 ).