Ischemia augments alloimmune injury through IL-6-driven CD4⁺ alloreactivity.

Of note, APC depletion led to a highly significant reduction in frequency of CD8 + IFNγ + T cells in ischemic grafts as compared to non-depleted ischemic grafts (compare to Fig. 2D ) (0.12 ± 0.02% vs. 27.7 ± 2.46%, *** p < 0.001).

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