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Soluble uric acid increases PDZK1 and ABCG2 expression in human intestinal cell lines via the TLR4-NLRP3 inflammasome and PI3K/Akt signaling pathway.

Arthritis Res Ther · 2018 · PMC5803867 · PMID 29415757

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an increasing trendno p-value reported
An increasing trend in the prevalence of gout and hyperuricemia has been revealed by epidemiological investigations in several western countries [ 3 , 4 ].

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