Barely Significant
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Evaluating the Energetic Driving Force for Cocrystal Formation.

Cryst Growth Des · 2018 · PMC5806084 · PMID 29445316

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a slight trendno p-value reported
Indeed, there is a slight trend for structures which do gain in hydrogen bonds to be less stable on average as the number of hydrogen bonds increases above 0.5 per molecule, though this is unlikely to be significant.

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