Unique molecular events during reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) at naïve state.

Dynamic changes in differentially methylated C sites (DMCs) throughout naïve reprogramming also showed an increasing trend of hypomethylated C site ratios ( Figure 4—figure supplement 1C ), a result consistent with the global demethylation trend ( Figure 4A ; Figure 4—figure supplement 1A, B ).

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