Low-burden TP53 mutations in chronic phase of myeloproliferative neoplasms: association with age, hydroxyurea administration, disease type and JAK2 mutational status.

The comparison of patients carrying TP53 mutation ( TP53 -mut) to patients without TP53 mutation ( TP53 -wt) revealed a highly significant association between TP53 mutations and higher age ( P =5.54 × 10 −5 ; median age at sampling 69.3 for TP53 -mut and 62.4 for TP53 -wt; Figure 2a ).

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