Tolerance and Tachyphylaxis to Head Twitches Induced by the 5-HT2A Agonist 25CN-NBOH in Mice.

As shown for the 1.5-h interval, a reduced but still highly significant loss of drug efficacy could likewise be demonstrated when 25CN-NBOH was injected twice at a lower dose (0.75 mg/kg, s.c.) to handling-habituated mice (mean ± SEM [% of the original responsiveness]: 30.66 ± 5.86; first vs. second injection, p ≤ 0.01) (Figure 4 ).

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