Knockdown of L1CAM significantly reduces metastasis in a xenograft model of human melanoma: L1CAM is a potential target for anti-melanoma therapy.

PLoS One · 2018 · PMC5809060 · PMID 29432466

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highly significantno p-value reported

According to our results, L1CAM could be a promising target for combination therapy of human melanoma as a knockdown of L1CAM alone already led to a highly significant decrease in metastasis in the xenograft model of human melanoma described in this study even without changes in glycoprotein core-fucosylation by FUT8[ 12 ].

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