Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex.

Cell Rep · 2018 · PMC5813697 · PMID 29386113

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closest p · 1.2× alpha

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a trend toward significancep = 0.06so close (0.05 < p ≤ 0.1)

These results are consistent with biomembrane force probe (BFP) 2D affinity measurements of the 3.L2 TCR that showed no contribution of CD4 to the agonist Hb:I-E k pMHCII, but a significant contribution to binding of an antagonist (I72) pMHCII and a trend toward significance with a weak agonist ligand (T72; p = 0.06) ( Hong et al., 2015 ).

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