Expression of cell cycle regulators and frequency of TP53 mutations in high risk gastrointestinal stromal tumors prior to adjuvant imatinib treatment.

Surprisingly, we detected a marginal significance between the lack of CCND1 (cyclin D1) expression and larger tumors.

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Therefore, many large GISTs with a small mitotic count were included in the trial, which explains the marginally significant association between absence of CCND1 expression and a small tumor diameter.

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