Fever of unknown origin and splenomegaly: A case report of blood culture negative endocarditis.

Blood cultures, in fact, are often negative and the serologic methods currently used are limited by their poor specificity (in some case series, a cross-reaction between Bartonella species and Coxiella and Clamydia species was demonstrated) and by the absence of a defined significant titers, even if an IgG titer of >800 could be considered significant.

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