This observation may be significant for prognosis, as EpCAM-CTCs from the blood samples of breast cancer patients may produce a specific population of CTCs (positive for human epidermal growth factor receptor 2/epidermal growth factor receptor/heparanase/Notch1), which metastasize to brain tissue ( 109 ).
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Molecular regulation of epithelial-to-mesenchymal transition in tumorigenesis (Review).
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