Statistical analysis for toxicity studies.

Because Dunnett test calculates critical values considering multiplicity, with comparisons (three in the example in Table 2 ) conducted simultaneously, the critical value is large, compared with that in the Student’s t -test, and it is less likely to be significant.

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The critical value of Dunnett test (DF, degree of freedom = 36) in this example is 2.452, and the comparison between the control and middle-dose group is barely significant.

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