As expected, insulin increased expression of Pck1 and G6pc when compared to those in the LPS/V group; however, both of which were diminished in LPS/KD+Ins rats although the change of Pck1 did not achieve significance (Fig. 8 D).
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Hypothalamic POMC expression is required for peripheral insulin action on hepatic gluconeogenesis through regulating STAT3 in sepsis rats.
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