Kynurenic acid accumulation underlies learning and memory impairment associated with aging.

Genes Dev · 2018 · PMC5828390 · PMID 29386332

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marginally significantno p-value reported

While nkat-1 RNAi improved learning capacity to an extent similar to that of the nkat-1 deletion mutants and dependent on nmr-1 , nkat-1 RNAi resulted in a marginally significant decrease of 17% in KYNA levels extracted from young animals and no statistically significant change in the highly elevated KYNA levels of day 7 adults ( Supplemental Fig.

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