Langerhans Cells Prevent Autoimmunity via Expansion of Keratinocyte Antigen-Specific Regulatory T Cells.

Highly significant changes included decreased expression of Ciita , a regulator of MHC II, and increased Tgfb1 and Smad3 expression ( Fig. 5 D), both of which are associated with TGF-β signaling and LC migration ( Mohammed et al., 2016 ).

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