Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR-mediated direct in vivo screening.

Of all 1540 possible gene pairs, we found that a total of 226 pairs were significantly enriched beyond what would be expected by chance (hypergeometric test, Benjamini-Hochberg–adjusted, P < 0.05), with highly significant pairs such as Cdkn2a + Pten (co-occurrence rate = 7/10 = 70%; hypergeometric test, P = 2.63 × 10 −5 ), Cdkn2a + Rasa1 (co-occurrence rate = 6/9 = 67%; P = 7.96 × 10 −5 ), Arid2 + Cdkn1b (co-occurrence rate = 11/17 = 65%; P = 9.13 × 10 −5 ), and B2m + Kansl1 (co-occurrence rate = 11/18 = 61%; P = 3.6 × 10 −4 ; Fig. 5 , B and C, and table S13).

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