a nonsignificant trendP = 0.0678
In the high-risk cohort, patients treated with Glar-300 showed a nonsignificant trend toward lower nocturnal hypoglycemia compared with those treated with Glar-100 [25.3% versus 38.0% ( P = 0.0678) for the EDITION 2 trial and 24.2% versus 32.7% ( P = 0.1903) for the EDITION 3 trial].