Regarding Akti-1/2, AZD8330, ERK inhibitor II and 2-Bromoaldisine the rescue effect of CD40L is hardly influenced by the additional pathway inhibition and the rescue effect is still highly significant, with only one exception (ERK inhibitor II in combination with ibrutinib).
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CD40L mediated alternative NFκB-signaling induces resistance to BCR-inhibitors in patients with mantle cell lymphoma.
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