Pharmacological activation of autophagy favors the clearing of intracellular aggregates of misfolded prion protein peptide to prevent neuronal death.

Noteworthy, the protective effect of serum withdrawal and rapamycin were dependent on PrP90-231 concentration, being highly significant for concentration between 1 and 3 μM, and less effective for lower (0.1–0.3 μM) or higher (10 μM) concentrations.

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