Metformin-induced caveolin-1 expression promotes T-DM1 drug efficacy in breast cancer cells.

Sci Rep · 2018 · PMC5834501 · PMID 29500444

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a numerical trendno p-value reported

Although T-DM1 treatment did not result in significant improvement of PFS, subgroup analyses showed a numerical trend of an increasing beneficial effect of T-DM1 in patients who had received HER-2-directed therapy or taxanes during early treatment 10 .

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