Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells.

Front Immunol · 2018 · PMC5835137 · PMID 29535740

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highly significantno p-value reported

Blockade of PD-1 resulted in slightly enhanced proliferation (fold change 1.15; n = 13; p = 0.002), and blockade of LAG-3 lead to markedly enhanced proliferation (fold change 1.44; n = 9; p = 0.002), both statistically highly significant (Figure 3 A).

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