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PD-1 (PDCD1) Promoter Methylation Is a Prognostic Factor in Patients With Diffuse Lower-Grade Gliomas Harboring Isocitrate Dehydrogenase (IDH) Mutations.

EBioMedicine · 2018 · PMC5835568 · PMID 29396294

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highly significantno p-value reported
Discussion In the present study, DNA promoter methylation of the immune checkpoint PD-1 was shown to serve as highly significant prognostic factor for overall survival in patients with LGG.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.