borderline significancep = 0.056
However, when the LRIG1-null cells were transfected with LRIG1, the shRNA mediated down-regulation of PON2, and ZBTB16 induced up-regulation and down-regulation (borderline significance, p = 0.056) of PDGFRA expression, respectively, similar to the findings observed in wildtype HEK293 cells ( Fig. 6 B ).