Secular Trends on Birth Parameters, Growth, and Pubertal Timing in Girls with Turner Syndrome.

To determine whether age at spontaneous puberty and age at the start of GH in patients with TS are associated, we performed a correlation analysis, revealing a highly significant correlation between age at the start of GH treatment and age at pubertal onset [correlation coefficient 0.65 ( p -value < 0.0001)], which explained 32% of the variability in spontaneous puberty with age at GH start [intercept = 10.3 years ( p < 0.0001), slope = 0.31 ( p < 0.0001)].

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