The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden.CETP mice.

However, in W4, W8, W12, and W18 AT04A vaccine treated mice showed a highly significant decrease in PCSK9 concentration of 57, 59, 49, and 24%, respectively ( P < 0.001, P < 0.001, P = 0.001, and P = 0.029, respectively) ( Figure 1 B ) demonstrating a consistent and long-lasting effectiveness of the AT04A vaccine ( Figure 1 C ).

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