Barely Significant
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Tapentadol Prolonged Release Reduces the Severe Chronic Ischaemic Pain and Improves the Quality of Life in Patients with Type 2 Diabetes.

J Diabetes Res · 2018 · PMC5838502 · PMID 29675431

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highly significantno p-value reported
At the end of the study, the frequencies of responders at both 30% (88%) and 50% (76%) were very high, with a reduction in pain intensity of about 5 points on a numerical scale from 0 to 10, which was highly significant both clinically and statistically.

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