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Older mothers and increased impact of prenatal screening: stable livebirth prevalence of trisomy 21 in the Netherlands for the period 2000-2013.

Eur J Hum Genet · 2018 · PMC5839038 · PMID 29330546

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a decreasing trendno p-value reported
Furthermore, a decreasing trend in the number of performed prenatal invasive tests is present.

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