Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis.

Pathway enrichment analysis and metabolic map reconstruction, using the metabolites whose changes in abundance discriminated untreated and treated cells (Supplementary Table S1 ), revealed highly significant enrichment for the pathway targeted by FR054, amino sugar metabolism, and the glutamate/glutathione metabolism interconnected with pantothenate/CoA biosynthesis (Supplementary Figure 6B-C ).

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