Ketamine independently modulated power and phase-coupling of theta oscillations in Sp4 hypomorphic mice.

These effects on theta power included: a highly significant reduction at frontal sites (p = 1.55×10 −4 ) and a marginally significant reduction at parietal sites (p = 0.0499) in Sp4 hypomorphic animals, as well as a slight but significant increase at occipital sites (p = 0.0203) in wildtype animals ( Fig 4B ).

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