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A National Registry of Thalassemia in Turkey: Demographic and Disease Characteristics of Patients, Achievements, and Challenges in Prevention.

Turk J Haematol · 2018 · PMC5843769 · PMID 28404539

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a decreasing trendno p-value reported
Cardiac disease was detected as a major cause of death and did not show a decreasing trend in 5-year cohorts since 1999.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.