Dopamine D2 Receptors in Dopaminergic Neurons Modulate Performance in a Reversal Learning Task in Mice.

This hypothesis was evaluated using a one-tailed t test, revealing a statistical trend for autoDrd2-KO mice to require more trials than wild-type controls to reach criterion performance during reversal learning ( t (39) = 1.696, p = 0.051; Fig. 3 A ).

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We identified a pronounced trend in autoDrd2-KO animals to require more trials before reaching criterion after reversal of learning contingencies, although this effect did not reach a conventional significance level.

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