The Long Pentraxin 3 Plays a Role in Bone Turnover and Repair.

Distal femora from young adult ptx3 −/− females (10–12 weeks old) on B6 background showed highly significant decrease in trabecular bone volume ( p < 0.0001), which was paralleled by decreased trabecular number and trabecular thickness, as well as increased trabecular separation compared to ptx3 +/+ mice (Figure 1 ).

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Difference in distal femoral trabecular bone volume was marginally significant between ptx3 −/− and ptx3 +/+ males ( p = 0.0435), with lower trabecular number in ptx3 −/− mice.

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