Exhaustion of the CD8⁺ T Cell Compartment in Patients with Mutations in Phosphoinositide 3-Kinase Delta.

Although a negative correlation was already observed for healthy controls (Figure 3 F), the correlation between the frequencies of PD-1 + CD160 + CD244 + CD8 + T cells and naive CD8 + T cells was highly significant in APDS patients (Figure 3 F).

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