highly significantp < 0.0001
When comparing the correlations among mutational impacts defined by our MD metrics (i.e., dCORR and dFLUX), we find a highly significant correlation between dCORR values for DNA and RNA ( r = 0.58, p < 0.0001) and between dCORR values in DNA and dFLUX values in RNA ( r = 0.55, p < 0.0001).