T-cell Immunoglobulin and ITIM Domain Contributes to CD8⁺ T-cell Immunosenescence.

This novel finding is highly significant, as targeting TIGIT might be an effective strategy to improve the immune response and decrease age‐related comorbidities. 4 EXPERIMENTAL PROCEDURES 4.1 Subjects The study was approved by the Committee of Ethics at Beijing Ditan Hospital, Capital Medical University, Beijing, China.

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