circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1.

Cell Death Dis · 2018 · PMC5852113 · PMID 29540674

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a decreasing trendno p-value reported

Moreover, although specific knockdown of circHECTD1 induced a decreasing trend in the expression of the hectd1 mRNA, the circHECTD1-siRNA not only increased the level of the HECTD protein in the normal MML1 cells but also restored the HECTD1 level in MML1 cells exposed to SiO 2 (Fig. 6e–g ), indicating a role for HECTD1 in the SiO 2 -induced EndMT.

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