an increasing trendp < 0.0001
An increasing trend was observed among persons less than 50 years, with rates at 2.3 per 100,000 (APC = 2.7; p < 0.0001) for persons <40 years, and 22.5 per 100,000 (APC = 1.7; p < 0.001) for those between 40 and 49 years.