Insights into the Molecular Mechanisms of Alzheimer's and Parkinson's Diseases with Molecular Simulations: Understanding the Roles of Artificial and Pathological Missense Mutations in Intrinsically Disordered Proteins Related to Pathology.

For the C-terminal region, they noted an interesting trend in the helix structures; Ile31–Met35 adopted more abundant α-helix in the structures of the E22Δ mutant Aβ 40 in comparison to the same region in its WT form, while the opposite trend was detected for the same residues of the E22Δ mutant and WT Aβ 42 peptides ( Figure 8 ).

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