One study on C57BL/6 mice reported the time-dependent hepatotoxicity of TP, accompanied by an increasing trend of AST and ALT in the serum at 6 and 12 h, a peak at 24 h after TP (600 mg/kg) administration, and a decrease after 24 h [ 63 ].
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The Effect of Triptolide in Rheumatoid Arthritis: From Basic Research towards Clinical Translation.
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