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Trends in warfarin use and its associations with thromboembolic and bleeding rates in a population with atrial fibrillation between 1996 and 2011.

PLoS One · 2018 · PMC5856343 · PMID 29547673

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an increasing trendno p-value reported
Similarly, we observed an increasing trend.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.