Overlapping expression patterns and functions of three paralogous P5B ATPases in Caenorhabditis elegans.

catp-6(0) mutants present a highly significant smaller brood size when compared to N2 ( Table 1 , group c, ANOVA, Tukey post-hoc test, adj. p -value = 0.000000416).

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Given the known association between P5B ATPase function and Parkinsons disease, it may be significant that the human ortholog of vab-3 is Pax6, which has been shown to be important for dopaminergic neuron survival [ 53 ].

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