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Prevalence of malocclusion in primary dentition in mainland China, 1988-2017: a systematic review and meta-analysis.

Sci Rep · 2018 · PMC5856803 · PMID 29549346

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an increasing trendno p-value reported
An increasing trend and wide variations across the country were observed.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.